Page 21 - Inspire Magazine

Available NICE SMC Useage
Treatments: Type: Sub types: approved: approved: (this is stage dependent):
Pembrolizumab Immunotherapy PDL1+ non-small YES YES 1st line where PDL1 status
(Keytruda®) cell lung cancer +2nd/3rd line if ALK + and
EGFR +

Nivolumab Immunotherapy NSCLC YES YES 2nd line
(Opdivo®) non-advanced/ (via CDF)
metastatic squamous

Atezolizumab Immunotherapy YES YES 2nd line post
(Tecentriq®) (via PAS) chemotherapy, or 3rd line
usage ALK+ or EGFR+

Crizotinib Targeted therapy YES YES 1st line for locally advanced
(Xalkori®) (via CDF or metastatic disease for
for ROS1) ALK+

Certinib Targeted therapy ALK+ YES YES 1st line via NICE CDF or
(Zykadia®) (via CDF) 2nd line treatment in
Scot. for locally advanced
ALK+ or metastatic disease
ROS1

Alectinib Targeted therapy ALK+ YES YES 1st line
(Alecensa®) Advanced NSCLC (via PAS) (via PAS)

Nintedanib Targeted therapy NSCLC Adeno- YES YES 2nd line
(Vargatef®) carcinoma ALK+

Erlotinib Targeted therapy EGFR+ locally YES YES 1st line
(Tarceva®) advanced / (via PAS) 2nd line for lung cancer
metastatic disease recurrence

Gefitinib Targeted therapy EGFR+ locally YES YES 1st and 2nd line
(Iressa®) advanced / (via PAS)
metastatic disease

Osimertinib Targeted therapy EGFR+ T790 YES YES 2nd line
(Tagrisso®) mutation (via CDF) (via PAS)

*Information correct at time of publishing (Oct. 2018)
Source: NICE, SMC, EMA, Cancer Research UK
Jackie’s Story:
New treatments are the reason I’m still here Chances were, I wasn’t going to live long
“I was diagnosed with terminal lung cancer at myself.
44. My diagnosis came completely out of the
blue – I’d been living a relatively healthy life, That was four years ago and, contrary to
exercising regularly, eating well. I needed to be expectations, I’m still here and this is because
in good shape – we were trying to have a baby. of the ongoing advances in treatments.

But that wasn’t to be. Instead, scans found lung I am currently on my sixth line of treatment.
cancer, widespread lung cancer, terminal lung I’ve had 13 cycles of chemotherapy,
cancer. I had metastases in my bones, brain, left radiotherapy six times. Immunotherapy
adrenal gland and a small but active primary didn’t work for me. I’m now on the
active tumour in my left lung. I wasn’t going to targeted therapy osimertinib. Without it, INSPIRE 2018
have life growing inside me. it’s unlikely I’d be here today.”

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